| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
|---|
| Ligand | BDBM50126186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1651274 (CHEMBL4000529) |
|---|
| IC50 | 3600±n/a nM |
|---|
| Citation |  Waghorn, PA; Jackson, MR; Gouverneur, V; Vallis, KA Targeting telomerase with radiolabeled inhibitors. Eur J Med Chem125:117-129 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomerase reverse transcriptase |
|---|
| Name: | Telomerase reverse transcriptase |
|---|
| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 127099.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1447029 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
|
|
|
|---|
| BDBM50126186 |
|---|
| n/a |
|---|
| Name | BDBM50126186 |
|---|
| Synonyms: | 2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic acid | CHEMBL27323 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17NO3 |
|---|
| Mol. Mass. | 331.3646 |
|---|
| SMILES | C\C(=C/C(=O)Nc1ccccc1C(O)=O)c1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
