Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM50234217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1652543 (CHEMBL4001798) |
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IC50 | 22±n/a nM |
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Citation | Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Stein, AJ; Holt, M; Valentine, J; Zavadoski, W Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett27:413-419 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM50234217 |
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n/a |
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Name | BDBM50234217 |
Synonyms: | CHEMBL4104549 |
Type | Small organic molecule |
Emp. Form. | C27H25ClF5N5O3 |
Mol. Mass. | 597.964 |
SMILES | Nc1nc(O[C@H](c2ccc(Cl)cc2-c2cc(F)cc(F)c2)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 |r| |
Structure |
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