| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP12 |
|---|
| Ligand | BDBM50234915 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1654149 (CHEMBL4003515) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Nathubhai, A; Haikarainen, T; Koivunen, J; Murthy, S; Koumanov, F; Lloyd, MD; Holman, GD; Pihlajaniemi, T; Tosh, D; Lehtiö, L; Threadgill, MD Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem60:814-820 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein mono-ADP-ribosyltransferase PARP12 |
|---|
| Name: | Protein mono-ADP-ribosyltransferase PARP12 |
|---|
| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 79092.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107665 |
|---|
| Residue: | 701 |
|---|
| Sequence: | MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
|
|
|
|---|
| BDBM50234915 |
|---|
| n/a |
|---|
| Name | BDBM50234915 |
|---|
| Synonyms: | CHEMBL4069447 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H23N5O3 |
|---|
| Mol. Mass. | 477.5139 |
|---|
| SMILES | Cc1cccc2c1nc(CCC(=O)Nc1ccc(cc1)C(=O)Nc1cccc3cccnc13)[nH]c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
