Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50042976 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1654734 (CHEMBL4004100) |
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IC50 | 33300±n/a nM |
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Citation | Jesus, AR; Vila-Viçosa, D; Machuqueiro, M; Marques, AP; Dore, TM; Rauter, AP Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J Med Chem60:568-579 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50042976 |
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n/a |
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Name | BDBM50042976 |
Synonyms: | (E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone | (E)-3-phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one | 2',4',6'-trihydroxychalcone | 3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone | CHEMBL129371 |
Type | Small organic molecule |
Emp. Form. | C15H12O4 |
Mol. Mass. | 256.2534 |
SMILES | Oc1cc(O)c(C(=O)\C=C\c2ccccc2)c(O)c1 |
Structure |
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