| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
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| Ligand | BDBM93618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654733 (CHEMBL4004099) |
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| IC50 | 7900±n/a nM |
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| Citation |  Jesus, AR; Vila-Viçosa, D; Machuqueiro, M; Marques, AP; Dore, TM; Rauter, AP Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J Med Chem60:568-579 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 1 |
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| Name: | Sodium/glucose cotransporter 1 |
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| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 73503.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P13866 |
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| Residue: | 664 |
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| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
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| BDBM93618 |
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| n/a |
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| Name | BDBM93618 |
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| Synonyms: | 3-phenyl-1-(2,4,6-trihydroxyphenyl)-1-propanone | 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one | 3-phenyl-1-[2,4,6-tris(oxidanyl)phenyl]propan-1-one | MLS000863605 | SMR000440736 | cid_1226045 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14O4 |
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| Mol. Mass. | 258.2693 |
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| SMILES | Oc1cc(O)c(C(=O)CCc2ccccc2)c(O)c1 |
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| Structure | 
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