| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-galactosidase |
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| Ligand | BDBM50235812 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657978 (CHEMBL4007590) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Front, S; Biela-Banas, A; Burda, P; Ballhausen, D; Higaki, K; Caciotti, A; Morrone, A; Charollais-Thoenig, J; Gallienne, E; Demotz, S; Martin, OR (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomalß-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. Eur J Med Chem126:160-170 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-galactosidase |
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| Name: | Beta-galactosidase |
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| Synonyms: | Acid beta-galactosidase | BGAL_HUMAN | ELNR1 | Elastin receptor 1 | GLB1 | Lactase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76074.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_215886 |
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| Residue: | 677 |
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| Sequence: | MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVIL
RPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPV
ITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTV
DFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARG
ASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKV
PEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENM
GRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWA
HNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLT
LFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKR
LMPPPPQKNKDSWLDHV
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| BDBM50235812 |
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| n/a |
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| Name | BDBM50235812 |
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| Synonyms: | CHEMBL4085739 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H23NO3 |
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| Mol. Mass. | 217.3052 |
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| SMILES | CCCCC[C@H]1NC[C@@H](O)[C@@H](O)[C@H]1CO |r| |
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| Structure | 
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