| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Ligand | BDBM50044626 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658472 (CHEMBL4008084) |
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| IC50 | 3000±n/a nM |
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| Citation |  Capranico, G; Marinello, J; Chillemi, G Type I DNA Topoisomerases. J Med Chem60:2169-2192 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Name: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Synonyms: | DNA helicase, RecQ-like type 3 | Exonuclease WRN | RECQ3 | RECQL2 | RecQ protein-like 2 | WRN | WRN_HUMAN | Werner syndrome ATP-dependent helicase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 162454.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105140 |
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| Residue: | 1432 |
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| Sequence: | MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
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| BDBM50044626 |
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| n/a |
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| Name | BDBM50044626 |
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| Synonyms: | CHEMBL1374426 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H9NO4 |
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| Mol. Mass. | 183.1614 |
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| SMILES | CCC(=O)OCN1C(=O)C=CC1=O |c:9| |
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| Structure | 
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