Reaction Details |
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Target | Lysine-specific histone demethylase 2 |
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Ligand | BDBM50236365 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1659160 (CHEMBL4008772) |
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IC50 | >100000±n/a nM |
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Citation | Sartori, L; Mercurio, C; Amigoni, F; Cappa, A; Fagá, G; Fattori, R; Legnaghi, E; Ciossani, G; Mattevi, A; Meroni, G; Moretti, L; Cecatiello, V; Pasqualato, S; Romussi, A; Thaler, F; Trifiró, P; Villa, M; Vultaggio, S; Botrugno, OA; Dessanti, P; Minucci, S; Zagarrí, E; Carettoni, D; Iuzzolino, L; Varasi, M; Vianello, P Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration. J Med Chem60:1673-1692 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific histone demethylase 2 |
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Name: | Lysine-specific histone demethylase 2 |
Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 |
Type: | PROTEIN |
Mol. Mass.: | 92112.91 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_992590 |
Residue: | 822 |
Sequence: | MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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BDBM50236365 |
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n/a |
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Name | BDBM50236365 |
Synonyms: | CHEMBL4090002 |
Type | Small organic molecule |
Emp. Form. | C27H29N3O3S |
Mol. Mass. | 475.602 |
SMILES | CN1CCC(CC1)Oc1ccc(OCc2cccc(NC(=O)c3cc4sccc4n3C)c2)cc1 |
Structure |
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