Reaction Details |
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Target | NADPH--cytochrome P450 reductase |
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Ligand | BDBM50236853 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1659516 (CHEMBL4009128) |
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IC50 | 6300±n/a nM |
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Citation | Bian, J; Li, X; Wang, N; Wu, X; You, Q; Zhang, X Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile. Eur J Med Chem129:27-40 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NADPH--cytochrome P450 reductase |
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Name: | NADPH--cytochrome P450 reductase |
Synonyms: | CYPOR | Cytochrome P450 Reductase (CPR) | NADPH--cytochrome P450 reductase | NCPR_HUMAN | P450R | POR |
Type: | Enzyme |
Mol. Mass.: | 76675.22 |
Organism: | Homo sapiens (Human) |
Description: | P16435 |
Residue: | 677 |
Sequence: | MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTL
TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLA
DLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEH
FNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEES
SIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHL
MHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHP
FPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV
VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYET
KAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPF
IGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQS
HKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVD
YIKKLMTKGRYSLDVWS
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BDBM50236853 |
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n/a |
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Name | BDBM50236853 |
Synonyms: | CHEMBL4094677 |
Type | Small organic molecule |
Emp. Form. | C14H10O3 |
Mol. Mass. | 226.2274 |
SMILES | Cc1coc-2c1C(=O)C(=O)c1ccc(C)cc-21 |
Structure |
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