| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 1 |
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| Ligand | BDBM20461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1659962 (CHEMBL4009574) |
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| IC50 | 29000±n/a nM |
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| Citation |  Al-Sabi, A; Daly, D; Hoefer, P; Kinsella, GK; Metais, C; Pickering, M; Herron, C; Kaza, SK; Nolan, K; Dolly, JO A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction. J Med Chem60:2245-2256 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 1 |
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| Name: | Potassium voltage-gated channel subfamily A member 1 |
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| Synonyms: | KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56451.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Potassium (voltage dependent) 0 0::Q09470 |
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| Residue: | 495 |
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| Sequence: | MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF
FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT
ANQNCVNKSKLLTDV
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| BDBM20461 |
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| n/a |
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| Name | BDBM20461 |
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| Synonyms: | (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide | CAP | CHEMBL294199 | Capsaicin | Zostrix |
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| Type | n/a |
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| Emp. Form. | C18H27NO3 |
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| Mol. Mass. | 305.4119 |
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| SMILES | COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O |
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| Structure | 
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