| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM50373071 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1661619 (CHEMBL4011231) |
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| IC50 | 1300±n/a nM |
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| Citation |  Blevitt, JM; Hack, MD; Herman, KL; Jackson, PF; Krawczuk, PJ; Lebsack, AD; Liu, AX; Mirzadegan, T; Nelen, MI; Patrick, AN; Steinbacher, S; Milla, ME; Lumb, KJ Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J Med Chem60:3511-3517 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM50373071 |
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| n/a |
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| Name | BDBM50373071 |
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| Synonyms: | CHEMBL255489 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32F3N3O2 |
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| Mol. Mass. | 547.6106 |
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| SMILES | CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12 |
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| Structure | 
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