Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM50237513 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1660138 (CHEMBL4009750) | ||
IC50 | 105±n/a nM | ||
Citation | Wu, YJ; Guernon, J; Shi, J; Ditta, J; Robbins, KJ; Rajamani, R; Easton, A; Newton, A; Bourin, C; Mosure, K; Soars, MG; Knox, RJ; Matchett, M; Pieschl, RL; Post-Munson, DJ; Wang, S; Herrington, J; Graef, J; Newberry, K; Bristow, LJ; Meanwell, NA; Olson, R; Thompson, LA; Dzierba, C Development of New Benzenesulfonamides As Potent and Selective Na J Med Chem60:2513-2525 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
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BDBM50237513 | |||
n/a | |||
Name | BDBM50237513 | ||
Synonyms: | CHEMBL4063378 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28F2N4O3S2 | ||
Mol. Mass. | 534.642 | ||
SMILES | Fc1cc(c(F)cc1OCC[C@@]1(CC[C@@H](CC1)NC1CC1)c1ccccc1)S(=O)(=O)Nc1ncns1 |r,wU:14.18,11.11,(31.13,-18.84,;31.91,-17.51,;33.45,-17.52,;34.23,-16.19,;33.46,-14.85,;34.23,-13.52,;31.92,-14.85,;31.16,-16.17,;29.62,-16.16,;28.85,-14.82,;27.31,-14.82,;26.54,-16.15,;25.18,-16.86,;25.14,-18.4,;26.44,-19.21,;27.8,-18.49,;27.85,-16.94,;26.39,-20.75,;25.04,-21.47,;23.52,-21.43,;24.24,-22.77,;25.44,-15.04,;23.94,-15.45,;22.84,-14.35,;23.24,-12.84,;24.75,-12.44,;25.85,-13.54,;35.77,-16.19,;36.18,-14.7,;37.26,-15.81,;36.53,-17.53,;38.07,-17.54,;38.98,-16.3,;40.44,-16.78,;40.44,-18.32,;38.97,-18.79,)| | ||
Structure |