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TargetMatrix metalloproteinase 12
LigandBDBM50238241
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663588
IC50 5.0±n/a nM
Citation Durham TBMarimuthu JToth JLLiu CAdams LMudra DRSwearingen CLin CChambers MGThirunavukkarasu KWiley MR A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose. J Med Chem 60:5933-5939 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix metalloproteinase 12
Name:Matrix metalloproteinase 12
Synonyms:Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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  Blast E-value cutoff:
BDBM50238241
n/a
NameBDBM50238241
Synonyms:CHEMBL4102193
TypeSmall organic molecule
Emp. Form.C17H18F3N3O3
Mol. Mass.369.3383
SMILESFC(F)(F)c1ccc(CCC(=O)NC[C@]2(NC(=O)NC2=O)C2CC2)cc1 |r|
Structure
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