| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2b |
|---|
| Ligand | BDBM50238389 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1663193 (CHEMBL4012874) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Falsini, M; Squarcialupi, L; Catarzi, D; Varano, F; Betti, M; Dal Ben, D; Marucci, G; Buccioni, M; Volpini, R; De Vita, T; Cavalli, A; Colotta, V The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A J Med Chem60:5772-5790 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2b |
|---|
| Name: | Adenosine receptor A2b |
|---|
| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 36341.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 332 |
|---|
| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
|
|
|
|---|
| BDBM50238389 |
|---|
| n/a |
|---|
| Name | BDBM50238389 |
|---|
| Synonyms: | CHEMBL4066559 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14N6O |
|---|
| Mol. Mass. | 318.3327 |
|---|
| SMILES | Nc1ccc(cc1)-n1nc2c(N)nc(cn2c1=O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
