| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acid ceramidase |
|---|
| Ligand | BDBM50238554 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1663372 (CHEMBL4013053) |
|---|
| IC50 | 14±n/a nM |
|---|
| Citation |  Ortega, JA; Arencibia, JM; La Sala, G; Borgogno, M; Bauer, I; Bono, L; Braccia, C; Armirotti, A; Girotto, S; Ganesan, A; De Vivo, M Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. J Med Chem60:5800-5815 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acid ceramidase |
|---|
| Name: | Acid ceramidase |
|---|
| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44662.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13510 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
|
|
|
|---|
| BDBM50238554 |
|---|
| n/a |
|---|
| Name | BDBM50238554 |
|---|
| Synonyms: | CHEMBL4094489 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21N3O2 |
|---|
| Mol. Mass. | 323.3889 |
|---|
| SMILES | COc1nc2ccccc2n1C(=O)NCCCCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
