Ki Summary

Reaction Details

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Target

N-formyl peptide receptor 2

Ligand

BDBM50238898

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1664517 (CHEMBL4014198)

IC50

273±n/a nM

Citation

Skovbakke, SL; Skovbakke, SL; Skovbakke, SL; Holdfeldt, A; Holdfeldt, A; Holdfeldt, A; Nielsen, C; Nielsen, C; Nielsen, C; Hansen, AM; Hansen, AM; Hansen, AM; Perez-Gassol, I; Perez-Gassol, I; Perez-Gassol, I; Dahlgren, C; Dahlgren, C; Dahlgren, C; Forsman, H; Forsman, H; Forsman, H; Franzyk, H; Franzyk, H; Franzyk, H Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists. J Med Chem60:6991-6997 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

N-formyl peptide receptor 2

Name:

N-formyl peptide receptor 2

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

38968.35

Organism:

Homo sapiens (Human)

Description:

P25090

Residue:

351

Sequence:

METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM

BDBM50238898

n/a

Name

BDBM50238898

Synonyms:

CHEMBL4094101

Type

Small organic molecule

Emp. Form.

C60H78N9O6

Mol. Mass.

1021.3175

SMILES

CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:33.34,wD:19.20,(20.03,-41.29,;18.7,-40.52,;18.7,-38.97,;20.03,-38.2,;21.36,-38.97,;17.35,-38.2,;17.34,-36.68,;16.01,-35.91,;14.69,-36.69,;13.35,-35.92,;13.34,-33.85,;11.99,-33.09,;11.99,-31.55,;13.32,-30.77,;14.66,-31.54,;14.66,-33.08,;15.99,-33.85,;15.99,-35.4,;17.34,-33.08,;18.7,-33.85,;18.7,-35.4,;20.03,-36.17,;20.03,-37.71,;21.36,-38.48,;22.7,-37.71,;20.05,-33.08,;20.05,-31.52,;21.39,-33.85,;21.39,-35.39,;22.73,-36.15,;24.06,-35.38,;24.06,-33.84,;25.4,-36.15,;26.73,-35.37,;26.72,-33.83,;28.05,-33.06,;28.05,-31.52,;29.38,-30.75,;29.38,-29.21,;28.06,-36.14,;28.07,-37.68,;29.39,-35.37,;30.73,-36.13,;30.73,-37.67,;32.07,-38.44,;32.07,-39.98,;33.4,-37.67,;29.39,-33.83,;30.72,-33.05,;32.05,-33.82,;33.38,-33.05,;33.38,-31.51,;32.04,-30.74,;30.71,-31.52,;22.72,-33.07,;22.72,-31.53,;24.05,-30.77,;24.05,-29.23,;22.71,-28.46,;21.38,-29.24,;21.39,-30.78,;12.01,-36.7,;10.68,-35.94,;9.36,-36.72,;9.38,-38.26,;10.7,-39.02,;12.03,-38.24,;13.37,-39,;14.69,-38.23,;16.03,-38.99,;8.03,-39.03,;6.69,-38.26,;5.36,-39.03,;8.03,-40.57,;6.69,-41.34,)|

Structure