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TargetN-formyl peptide receptor 2
LigandBDBM50238910
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664524 (CHEMBL4014205)
IC50 60±n/a nM
Citation Skovbakke, SL; Skovbakke, SL; Skovbakke, SL; Holdfeldt, A; Holdfeldt, A; Holdfeldt, A; Nielsen, C; Nielsen, C; Nielsen, C; Hansen, AM; Hansen, AM; Hansen, AM; Perez-Gassol, I; Perez-Gassol, I; Perez-Gassol, I; Dahlgren, C; Dahlgren, C; Dahlgren, C; Forsman, H; Forsman, H; Forsman, H; Franzyk, H; Franzyk, H; Franzyk, H Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists. J Med Chem60:6991-6997 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-formyl peptide receptor 2
Name:N-formyl peptide receptor 2
Synonyms:ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:38968.35
Organism:Homo sapiens (Human)
Description:P25090
Residue:351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238910
n/a
NameBDBM50238910
Synonyms:CHEMBL4103322
TypeSmall organic molecule
Emp. Form.C84H127N24O15
Mol. Mass.1713.0584
SMILESCCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:98.100,67.69,47.48,28.29,wD:87.89,74.76,58.60,39.40,19.20,(20.11,-29.83,;18.77,-29.06,;17.43,-29.83,;17.43,-31.37,;18.77,-32.14,;16.1,-29.06,;16.09,-27.53,;14.75,-26.76,;13.43,-27.54,;12.09,-26.77,;12.08,-24.71,;10.74,-23.95,;10.73,-22.4,;12.06,-21.63,;13.4,-22.39,;13.4,-23.93,;14.73,-24.69,;14.73,-26.24,;16.06,-23.92,;17.39,-24.69,;17.39,-26.23,;18.84,-27.12,;20.36,-26.84,;21.4,-28.17,;20.99,-25.64,;18.73,-23.92,;18.73,-22.38,;20.06,-24.69,;21.4,-23.92,;21.4,-22.38,;22.73,-21.61,;22.73,-20.06,;24.07,-19.3,;24.07,-17.77,;22.73,-16.99,;25.4,-16.99,;22.73,-24.69,;22.73,-26.23,;24.07,-23.92,;25.4,-24.69,;25.4,-26.23,;26.74,-27.01,;26.74,-28.55,;28.07,-26.23,;26.74,-23.92,;26.74,-22.38,;28.07,-24.69,;29.41,-23.92,;29.41,-22.38,;30.74,-21.61,;30.74,-20.06,;32.07,-19.3,;33.41,-20.06,;33.41,-21.61,;32.07,-22.38,;30.74,-24.69,;30.74,-26.23,;32.07,-23.92,;33.41,-24.69,;33.41,-26.23,;34.75,-27.01,;34.75,-28.55,;33.41,-29.31,;36.08,-29.31,;34.75,-23.92,;34.75,-22.38,;36.08,-24.69,;37.42,-23.92,;37.42,-22.38,;38.75,-21.61,;36.08,-21.61,;38.75,-24.69,;38.75,-26.23,;40.09,-23.92,;41.41,-24.69,;41.41,-26.23,;42.75,-27.01,;42.75,-28.55,;44.08,-29.31,;44.08,-30.85,;42.75,-23.92,;42.75,-22.38,;44.08,-24.69,;45.42,-23.92,;46.75,-24.69,;46.75,-26.23,;48.09,-23.92,;49.42,-24.69,;49.42,-26.23,;50.76,-27.01,;50.76,-28.55,;52.08,-29.31,;52.08,-30.85,;50.76,-31.63,;53.42,-31.63,;50.76,-23.92,;50.76,-22.38,;52.08,-24.69,;53.42,-23.92,;53.42,-22.38,;54.76,-21.61,;54.76,-20.06,;56.09,-19.3,;56.09,-17.77,;54.76,-16.99,;57.43,-16.99,;54.76,-24.69,;56.09,-23.92,;54.76,-26.23,;10.76,-27.55,;9.42,-26.8,;8.09,-27.57,;8.11,-29.11,;9.44,-29.87,;10.77,-29.09,;12.1,-29.86,;13.43,-29.08,;14.78,-29.85,;6.77,-29.88,;6.77,-31.42,;5.43,-32.19,;5.43,-29.11,;4.1,-29.88,)|
Structure
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