| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Death-associated protein kinase 2 |
|---|
| Ligand | BDBM50238989 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1664713 (CHEMBL4014509) |
|---|
| IC50 | 6340±n/a nM |
|---|
| Citation |  Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis. Eur J Med Chem130:195-208 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Death-associated protein kinase 2 |
|---|
| Name: | Death-associated protein kinase 2 |
|---|
| Synonyms: | DAP kinase 2 | DAP-kinase-related protein 1 | DAPK2 | DAPK2_HUMAN | DRP-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42900.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774557 |
|---|
| Residue: | 370 |
|---|
| Sequence: | MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSR
ASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKES
LSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIED
GVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANIT
AVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESV
VNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKA
LHPRRRSSTS
|
|
|
|---|
| BDBM50238989 |
|---|
| n/a |
|---|
| Name | BDBM50238989 |
|---|
| Synonyms: | CHEMBL4087337 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12O5 |
|---|
| Mol. Mass. | 284.2635 |
|---|
| SMILES | COc1ccc2O\C(=C/c3ccc(O)c(O)c3)C(=O)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
