| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50157884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1664931 (CHEMBL4014727) |
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| IC50 | 50119±n/a nM |
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| Citation |  Ballante, F; Reddy, DR; Zhou, NJ; Marshall, GR Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy. Bioorg Med Chem25:2105-2132 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HDAC8 | Histone deacetylase 8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49771.73 |
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| Organism: | Schistosoma mansoni |
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| Description: | ChEMBL_116785 |
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| Residue: | 440 |
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| Sequence: | MSVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVT
AFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLA
AASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPPETSPNRQTRV
LYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRG
RFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNF
YPNLNLDSDCDSECSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEE
VKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPHESHNKTLDSIQKHHRRILEQLRNYAD
LNKLIYDYDQVYQLYNLTGM
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| BDBM50157884 |
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| n/a |
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| Name | BDBM50157884 |
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| Synonyms: | 6-(2-Mercapto-acetylamino)-hexanoic acid phenylamide | 6-(2-mercaptoacetamido)-N-phenylhexanamide | CHEMBL178727 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N2O2S |
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| Mol. Mass. | 280.386 |
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| SMILES | SCC(=O)NCCCCCC(=O)Nc1ccccc1 |
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| Structure | 
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