| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
|---|
| Ligand | BDBM274822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 5.29±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent US9556179 Publication Date 1/31/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase I isoform epsilon |
|---|
| Name: | Casein kinase I isoform epsilon |
|---|
| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47340.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49674 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
|
|
|
|---|
| BDBM274822 |
|---|
| n/a |
|---|
| Name | BDBM274822 |
|---|
| Synonyms: | 2-fluoro-N-(6-(4-(4-fluoro- phenyl)-1,2-dimethyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)benzamide | US9556179, Compound 399 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H18F2N6O |
|---|
| Mol. Mass. | 444.4361 |
|---|
| SMILES | Cc1nc(c(-c2ccc3nc(NC(=O)c4ccccc4F)cn3n2)n1C)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
