| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
|---|
| Ligand | BDBM274977 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 126±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US9877957 Publication Date 1/30/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 2 |
|---|
| Name: | Diacylglycerol O-acyltransferase 2 |
|---|
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 43848.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96PD7 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
|---|
| BDBM274977 |
|---|
| n/a |
|---|
| Name | BDBM274977 |
|---|
| Synonyms: | N2-(tert-butyl)-N8-(quinolin-5-ylmethyl)-5- (3-(trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide | US9877957, Example 16 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H31F3N4O2 |
|---|
| Mol. Mass. | 560.6093 |
|---|
| SMILES | CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cccc2ncccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
