Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50095890 |
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Substrate/Competitor | n/a |
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Ki | 185±n/a nM |
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Comments | PDSP_1571 |
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Citation | Kongsamut, S; Roehr, JE; Cai, J; Hartman, HB; Weissensee, P; Kerman, LL; Tang, L; Sandrasagra, A Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol317:417-23 (1996) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50095890 |
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n/a |
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Name | BDBM50095890 |
Synonyms: | 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol | 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol | CHEMBL716 | QUETIAPINE |
Type | Small organic molecule |
Emp. Form. | C21H25N3O2S |
Mol. Mass. | 383.507 |
SMILES | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:13| |
Structure |
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