Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Endothelin-1 receptor | ||
| Ligand | BDBM85335 | ||
| Substrate/Competitor | n/a | ||
| Ki | 0.13±n/a nM | ||
| Comments | PDSP_1669 | ||
| Citation |  Ohlstein, EH; Nambi, P; Hay, DW; Gellai, M; Brooks, DP; Luengo, J; Xiang, JN; Elliott, JD Nonpeptide endothelin receptor antagonists. XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist. J Pharmacol Exp Ther286:650-6 (1998) [PubMed] | ||
| More Info.: | Get all data from this article | ||
| Endothelin-1 receptor | |||
| Name: | Endothelin-1 receptor | ||
| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 48736.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25101 | ||
| Residue: | 427 | ||
| Sequence: |
| ||
| BDBM85335 | |||
| n/a | |||
| Name | BDBM85335 | ||
| Synonyms: | SB 234551 | SB-234551 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H34N2O9 | ||
| Mol. Mass. | 614.6418 | ||
| SMILES | CCCCn1ncc(\C=C(/Cc2cc3OCOc3cc2OC)C(O)=O)c1-c1ccc(OC)cc1OCc1ccccc1C(O)=O |(5.96,3.45,;6.87,2.2,;8.4,2.36,;9.31,1.12,;10.84,1.28,;11.61,2.61,;13.11,2.29,;13.27,.76,;14.61,-.01,;15.94,.76,;15.94,2.3,;17.28,3.07,;18.61,2.3,;19.94,3.07,;21.41,2.6,;22.31,3.84,;21.41,5.09,;19.94,4.61,;18.61,5.38,;17.28,4.61,;15.94,5.38,;15.94,6.92,;17.28,-.01,;17.28,-1.55,;18.61,.76,;11.87,.13,;11.55,-1.37,;12.69,-2.4,;12.37,-3.91,;10.91,-4.38,;10.59,-5.89,;11.73,-6.92,;9.76,-3.35,;10.08,-1.85,;8.94,-.82,;7.47,-1.29,;6.33,-.26,;6.65,1.24,;5.51,2.27,;4.04,1.8,;3.72,.29,;4.86,-.74,;4.54,-2.24,;3.08,-2.72,;5.69,-3.28,)| | ||
| Structure | 
| ||