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TargetGALR1
LigandBDBM85168
Substrate/Competitorn/a
Ki 0.68±n/a nM
CommentsPDSP_1161
Citation Smith KEWalker MWArtymyshyn RBard JBorowsky BTamm JAYao WJVaysse PJBranchek TAGerald CJones KA Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels. J Biol Chem 273:23321-6 (1998) [PubMed]
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GALR1
Name:GALR1
Synonyms:Galanin R1 | Galanin receptor type 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38883.91
Organism:RAT
Description:Galanin R1 GALR1 RAT::Q62805
Residue:346
Sequence:
MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARS
KPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLV
SIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDS
NQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASK
KKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPII
YAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
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  Blast E-value cutoff:
BDBM85168
n/a
NameBDBM85168
Synonyms:M32
TypeSmall organic molecule
Emp. Form.C136H209N41O34
Mol. Mass.2962.369
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:111.115,131.138,95.103,84.88,68.80,52.59,20.28,4.4,2.2,145.150,161.166,162.169,179.184,188.193,199.204,wD:115.131,103.111,89.95,60.67,41.42,30.39,8.17,137.142,153.158,154.160,168.173,(13.69,11.51,;13.72,9.97,;12.46,9.14,;11.11,9.89,;12.54,7.63,;11.23,6.8,;9.89,7.48,;9.85,9.02,;8.62,6.65,;8.66,5.14,;10.01,4.43,;10.12,2.93,;11.51,2.18,;12.74,3.05,;14.16,2.37,;12.66,4.59,;11.27,5.26,;7.28,7.36,;5.97,6.57,;5.97,4.98,;4.67,7.32,;4.63,8.82,;5.93,9.65,;7.36,9.02,;8.39,10.12,;7.71,11.47,;6.13,11.19,;3.36,6.53,;2.02,7.16,;2.02,8.62,;.63,6.37,;.59,4.82,;1.94,3.99,;1.94,2.45,;3.24,1.66,;3.2,.08,;4.55,-.67,;1.86,-.67,;-.71,7.2,;-2.06,6.49,;-3.56,7.12,;-2.06,5.02,;-.75,4.11,;-1.19,2.65,;-2.69,2.61,;-3.16,4.03,;-4.63,4.43,;-4.98,5.93,;-5.77,3.36,;-7.24,3.84,;-8.27,2.73,;-7.91,1.19,;-9.73,3.08,;-10.12,4.59,;-9.02,5.7,;-9.41,7.2,;-7.51,5.26,;-10.84,2.06,;-12.34,2.37,;-12.66,3.8,;-13.41,1.27,;-13.05,-.2,;-11.59,-.59,;-10.48,.51,;-11.15,-2.06,;-14.87,1.7,;-15.98,.67,;-15.62,-.87,;-17.56,1.07,;-17.92,2.61,;-16.85,3.64,;-15.35,3.28,;-14.24,4.39,;-14.6,5.85,;-13.49,6.96,;-16.1,6.29,;-17.24,5.22,;-18.59,0,;-20.05,.44,;-20.45,1.9,;-21.12,-.67,;-22.54,-.28,;-23.65,-1.34,;-23.26,-2.81,;-25.19,-.99,;-25.55,.55,;-26.26,-2.02,;-27.73,-1.62,;-28.08,-.16,;-28.83,-2.69,;-28.44,-4.15,;-26.97,-4.63,;-30.3,-2.25,;-31.44,-3.28,;-31.09,-4.71,;-32.95,-2.81,;-33.3,-1.34,;-32.19,-.28,;-30.73,-.71,;-32.55,1.23,;-34.05,-3.92,;-35.56,-3.56,;-35.87,-2.14,;-36.63,-4.71,;-36.27,-6.13,;-34.8,-6.57,;-33.7,-5.5,;-34.41,-8.03,;-38.09,-4.23,;-39.23,-5.3,;-38.84,-6.76,;-40.7,-4.87,;-41.85,-5.93,;-43.27,-5.54,;-43.66,-4.03,;-44.46,-6.6,;-44.18,-8.11,;-42.64,-8.54,;-41.45,-7.59,;-40.11,-8.39,;-40.54,-9.93,;-39.71,-11.27,;-40.46,-12.66,;-41.96,-12.66,;-42.87,-11.35,;-42.12,-10.05,;-45.92,-6.13,;-47.07,-7.2,;-46.71,-8.66,;-48.57,-6.76,;-49.68,-7.83,;-41.05,-3.36,;-42.6,-2.89,;-39.91,-2.29,;13.88,6.88,;13.88,5.42,;15.19,7.67,;16.53,6.88,;16.53,5.38,;17.92,4.67,;19.18,5.46,;17.96,3.12,;17.84,7.71,;17.84,9.18,;19.18,7.04,;20.45,7.75,;20.49,9.25,;21.79,10.09,;21.83,11.59,;23.14,9.25,;21.79,7.04,;21.79,5.46,;23.14,7.75,;24.44,7,;24.48,5.5,;23.18,4.71,;25.79,4.75,;25.83,3.24,;25.71,7.75,;25.71,9.29,;27.01,6.92,;28.32,7.71,;28.32,9.25,;27.01,10.05,;29.66,10.01,;29.66,6.96,;29.66,5.46,;30.97,7.67,;32.31,6.88,;32.27,5.38,;33.62,4.59,;33.62,3.08,;34.88,2.37,;34.92,.83,;36.27,.04,;33.62,0,;33.66,7.63,;33.66,9.1,;35,6.88,;36.27,7.67,;36.27,9.18,;37.53,9.97,;37.53,11.47,;38.8,12.26,;36.19,12.26,;37.61,6.92,;37.61,5.38,;38.88,7.75,;40.18,7.04,;40.26,5.5,;41.61,4.71,;41.69,3.16,;42.99,2.49,;43.07,.95,;44.46,.16,;41.77,.04,;41.53,7.87,;41.49,9.25,;42.91,7.24,;44.22,7.99,;44.22,9.57,;45.56,10.32,;45.6,11.87,;46.99,12.66,;48.33,11.83,;49.68,12.58,;48.29,10.32,;46.91,9.53,;45.52,7.24,;46.79,8.07,;45.52,5.66,)|
Structure
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