| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Ligand | BDBM50026756 |
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| Substrate/Competitor | n/a |
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| Ki | 0.81±n/a nM |
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| Comments | PDSP_534 |
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| Citation |  Araujo, F; Ruano, D; Vitorica, J Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties. J Pharmacol Exp Ther290:989-97 (1999) [PubMed] |
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| More Info.: | Get all data from this article |
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| Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Synonyms: | Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS |
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| Type: | Enzyme |
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| Mol. Mass.: | 51770.21 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P62813 |
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| Residue: | 455 |
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| Sequence: | MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGL
GERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKI
WTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACP
LKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMT
THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR
NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPL
IKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDR
LSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
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| BDBM50026756 |
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| n/a |
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| Name | BDBM50026756 |
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| Synonyms: | 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine | CHEMBL13662 | CI-218872 | CL 218872 | CL218,872 | v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9F3N4 |
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| Mol. Mass. | 278.2326 |
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| SMILES | Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F |
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| Structure | 
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