| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily H member 8 |
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| Ligand | BDBM50094703 |
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| Substrate/Competitor | n/a |
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| Ki | >10000±n/a nM |
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| Comments | PDSP_2986 |
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| Citation |  Jarvis, MF; Yu, H; Kohlhaas, K; Alexander, K; Lee, CH; Jiang, M; Bhagwat, SS; Williams, M; Kowaluk, EA ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. J Pharmacol Exp Ther295:1156-64 (2000) [PubMed] |
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| More Info.: | Get all data from this article |
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| Potassium voltage-gated channel subfamily H member 8 |
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| Name: | Potassium voltage-gated channel subfamily H member 8 |
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| Synonyms: | Elk1 | Elk3 | KCNH8_RAT | Kcnh8 | Potassium Channel | Potassium voltage-gated channel subfamily H member 8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 123234.95 |
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| Organism: | RAT |
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| Description: | Q9QWS8 |
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| Residue: | 1102 |
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| Sequence: | MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
MQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEK
GDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQR
REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
YNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHK
FVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEE
EETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQE
ADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEP
RISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILS
PQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSL
VGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQS
ISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPL
ENFPVEVVTSTADVKDSKAINV
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| BDBM50094703 |
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| n/a |
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| Name | BDBM50094703 |
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| Synonyms: | 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine | 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine | ABT-702 | CHEMBL66089 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19BrN6O |
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| Mol. Mass. | 463.33 |
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| SMILES | Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1 |
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| Structure | 
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