Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM85530 |
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Substrate/Competitor | n/a |
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Ki | 557±n/a nM |
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Comments | PDSP_1358 |
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Citation | Rothman, RB; Baumann, MH; Savage, JE; Rauser, L; McBride, A; Hufeisen, SJ; Roth, BL Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation102:2836-41 (2000) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) |
Type: | Enzyme |
Mol. Mass.: | 51935.10 |
Organism: | Rattus norvegicus (Rat) |
Description: | P08909 |
Residue: | 460 |
Sequence: | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
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BDBM85530 |
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n/a |
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Name | BDBM85530 |
Synonyms: | Nor-d-fenfluramine | Nor-dexfenfluramine | Norfenfluramine | Norfenfluramine (+) | Norfenfluramine (-) | d-Norfenfluramine |
Type | Small organic molecule |
Emp. Form. | C10H12F3N |
Mol. Mass. | 203.2042 |
SMILES | C[C@H](N)Cc1cccc(c1)C(F)(F)F |
Structure |
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