| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2C |
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| Ligand | BDBM50073444 |
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| Substrate/Competitor | n/a |
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| Ki | 402±n/a nM |
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| Comments | PDSP_1905 |
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| Citation |  Rothman, RB; Baumann, MH; Savage, JE; Rauser, L; McBride, A; Hufeisen, SJ; Roth, BL Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation102:2836-41 (2000) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| 5-hydroxytryptamine receptor 2C |
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| Name: | 5-hydroxytryptamine receptor 2C |
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| Synonyms: | 5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51935.10 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P08909 |
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| Residue: | 460 |
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| Sequence: | MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
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| BDBM50073444 |
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| n/a |
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| Name | BDBM50073444 |
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| Synonyms: | 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one | CHEMBL621 | TRAZODONE |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClN5O |
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| Mol. Mass. | 371.864 |
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| SMILES | Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 |
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| Structure | 
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