| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 1 |
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| Ligand | BDBM50316376 |
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| Substrate/Competitor | n/a |
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| Ki | 3600±n/a nM |
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| Comments | PDSP_3687 |
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| Citation |  Johansen, TN; Stensbøl, TB; Nielsen, B; Vogensen, SB; Frydenvang, K; Sløk, FA; Bräüner-Osborne, H; Madsen, U; Krogsgaard-Larsen, P Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA. Chirality13:523-32 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Glutamate receptor ionotropic, kainate 1 |
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| Name: | Glutamate receptor ionotropic, kainate 1 |
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| Synonyms: | GRIK1_RAT | Glur5 | Glutamate receptor ionotropic kainate 1 | Glutamate receptor ionotropic, kainate | Glutamate receptor, ionotropic kainate 1 | Glutamate-Kainate | Grik1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 107860.82 |
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| Organism: | RAT |
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| Description: | P22756 |
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| Residue: | 949 |
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| Sequence: | MERSTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKF
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
SICNALEVPHIQTRWKHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDS
TGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLKEMKKSKEFYVIFDCSHETAAEIL
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRKLNIDNPHVSSIIEKWSME
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPCALGPRF
MNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGI
WNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEAYCL
DLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
WAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFI
VLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRFHGSKKESLGVEKCL
SFNAIMEELGISLKNQKKLKKKSRTKGKSSFTSILTCHQRRTQRKETVA
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| BDBM50316376 |
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| n/a |
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| Name | BDBM50316376 |
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| Synonyms: | (S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid | (S)-ACPA | CHEMBL602962 | S)-4-(2-amino-2-carboxyethyl)-5-methylisoxazole-3-carboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10N2O5 |
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| Mol. Mass. | 214.1754 |
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| SMILES | Cc1onc(C(O)=O)c1C[C@H](N)C(O)=O |r| |
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| Structure | 
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