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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 2 | ||
| Ligand | BDBM277181 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assays | ||
| IC50 | 25800±n/a nM | ||
| Citation |  Arasappan, A; Bungard, CJ; Frie, JL; Han, Y; Hoyt, SB; Manley, PJ; Meissner, RS; Perkins, JJ; Sebhat, IK; Wilkening, RR; Leavitt, KJ Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent US10072003 Publication Date 9/11/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 2 | |||
| Name: | Metabotropic glutamate receptor 2 | ||
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 95584.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14416 | ||
| Residue: | 872 | ||
| Sequence: |
| ||
| BDBM277181 | |||
| n/a | |||
| Name | BDBM277181 | ||
| Synonyms: | US10072003, Example 11-1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16F5N5O | ||
| Mol. Mass. | 449.3767 | ||
| SMILES | NC(=O)c1cc(c2CCN(Cc3ccnc(n3)C(F)(F)F)Cc2n1)-c1c(F)cccc1F |(8,2.31,;6.67,3.08,;6.67,4.62,;5.33,2.31,;5.33,.77,;4,,;2.67,.77,;1.33,,;,.77,;,2.31,;-1.33,3.08,;-2.67,2.31,;-2.67,.77,;-4,,;-5.33,.77,;-5.33,2.31,;-4,3.08,;-6.67,3.08,;-6.67,4.62,;-8,2.31,;-5.33,3.85,;1.33,3.08,;2.67,2.31,;4,3.08,;4,-1.54,;5.33,-2.31,;6.67,-1.54,;5.33,-3.85,;4,-4.62,;2.67,-3.85,;2.67,-2.31,;1.33,-1.54,)| | ||
| Structure | 
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