Ki Summary

Reaction Details

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Target

neuronal acetylcholine receptor subunit alpha-4

Ligand

BDBM50063218

Substrate/Competitor

n/a

30±n/a nM

Comments

PDSP_785

Citation

Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther302:1246-52 (2002) [PubMed] Article

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neuronal acetylcholine receptor subunit alpha-4

Name:

neuronal acetylcholine receptor subunit alpha-4

Synonyms:

Cholinergic, Nicotinic Alpha4Beta2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

81710.63

Organism:

Xenopus

Description:

Cholinergic, Nicotinic Alpha4Beta2 0 Xenopus::A9JRM3

Residue:

734

Sequence:

MGARIPRGARLSANMGARIPCGARLSANMGARIPCGARLSANMGARIPSGARLSANMGAR
IPRGASLSANMGARIPSGARLSANMGARIPSGARLSANMGARIPRGARLSANMGARAQTL
LLLLGGFFSTAFCHIETRAHAEERLLKGLFSGYNKWSRPVANISDAVMVRFGLSIAQLID
VDEKNQMMTTNVWVKQEWHDYKLRWDPLEYENVTSIRIPSELIWRPDIVLYNNADGDFAV
THLTKAHLFHDGRIKWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDRAKIDLISMH
SHVDQLDYWESGEWVIVNAVGNYNIKKYECCTEIYSDITYSFIIRRLPLFYTINLIIPCL
LISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI
FVTLFIIITVFVLNVHHRSPRTHTMPAWVRRTFLDVVPRVLFMKRPAKDNCKKLIESLHA
RSFNPPPRLWSEAEIEPAFASSSSASPTSQRPSPTSSCCHQLEQSPNAQVFCKSPSGQYS
MLCEESALTSCPSPKPETKLLSEAQPNLMPKVRSVSVQQMYTPKEANEGAVRCRSRSIQY
CFLHEDFSQANGQASSSPVAQKGNGNEPQPSSHTSPCTCKPKSQEKPVDPSQGAKTVNAK
EHHVLLMSPSLKLAIEGVHYIADHLRAEDADFSVKQDWKYVAMVIDRIFLWMFIIVCLLG
TVGLFLPPWLAGMI

BDBM50063218

n/a

Name

BDBM50063218

Synonyms:

(R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane(+/-) epibatidine | Epibatidine | rac-(2R)-2-(6-chloropyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane

Type

Small organic molecule

Emp. Form.

C11H13ClN2

Mol. Mass.

208.687

SMILES

Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|

Structure