| Reaction Details |
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 | Report a problem with these data |
| Target | neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM50119631 |
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| Substrate/Competitor | n/a |
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| Ki | 100±n/a nM |
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| Comments | PDSP_2901 |
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| Citation |  Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther302:1246-52 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | Cholinergic, Nicotinic Alpha4Beta2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 81710.63 |
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| Organism: | Xenopus |
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| Description: | Cholinergic, Nicotinic Alpha4Beta2 0 Xenopus::A9JRM3 |
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| Residue: | 734 |
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| Sequence: | MGARIPRGARLSANMGARIPCGARLSANMGARIPCGARLSANMGARIPSGARLSANMGAR
IPRGASLSANMGARIPSGARLSANMGARIPSGARLSANMGARIPRGARLSANMGARAQTL
LLLLGGFFSTAFCHIETRAHAEERLLKGLFSGYNKWSRPVANISDAVMVRFGLSIAQLID
VDEKNQMMTTNVWVKQEWHDYKLRWDPLEYENVTSIRIPSELIWRPDIVLYNNADGDFAV
THLTKAHLFHDGRIKWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDRAKIDLISMH
SHVDQLDYWESGEWVIVNAVGNYNIKKYECCTEIYSDITYSFIIRRLPLFYTINLIIPCL
LISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMI
FVTLFIIITVFVLNVHHRSPRTHTMPAWVRRTFLDVVPRVLFMKRPAKDNCKKLIESLHA
RSFNPPPRLWSEAEIEPAFASSSSASPTSQRPSPTSSCCHQLEQSPNAQVFCKSPSGQYS
MLCEESALTSCPSPKPETKLLSEAQPNLMPKVRSVSVQQMYTPKEANEGAVRCRSRSIQY
CFLHEDFSQANGQASSSPVAQKGNGNEPQPSSHTSPCTCKPKSQEKPVDPSQGAKTVNAK
EHHVLLMSPSLKLAIEGVHYIADHLRAEDADFSVKQDWKYVAMVIDRIFLWMFIIVCLLG
TVGLFLPPWLAGMI
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| BDBM50119631 |
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| n/a |
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| Name | BDBM50119631 |
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| Synonyms: | 5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | CHEMBL144958 | NOHEP |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N2O |
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| Mol. Mass. | 190.2417 |
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| SMILES | O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10| |
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| Structure | 
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