| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM249489 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity RBP4 Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 16.4±n/a nM |
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| Comments | extracted |
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| Citation |  Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent US10072016 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
|
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|
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| BDBM249489 |
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| n/a |
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| Name | BDBM249489 |
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| Synonyms: | US10072016, Compound 87 | US10407433, Compound 87 | US10913746, Compound 87 | US11649240, Compound 87 | US9434727, 87 | US9777010, Compound 87 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F5N4O |
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| Mol. Mass. | 442.4255 |
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| SMILES | CCN1CCc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1 |
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| Structure | 
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