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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B
LigandBDBM50010981
Substrate/Competitorn/a
Ki>10000±n/a nM
CommentsPDSP_3034
Citation Zhao, Y; Zhang, HT; O'Donnell, JM Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J Pharmacol Exp Ther305:565-72 (2003) [PubMed]  Article
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:DPDE4 | PDE4B_RAT | Pde4b | Phosphodiesterase 4B
Type:Enzyme Catalytic Domain
Mol. Mass.:83349.50
Organism:RAT
Description:P14646
Residue:736
Sequence:
MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVL
HAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVR
NNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLE
ETDIDIATEDKSLIDT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010981
n/a
NameBDBM50010981
Synonyms:(Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one(Ro 20-1724) | 4-(3-Butyl-4-methoxy-benzyl)-imidazolidin-2-one | CHEMBL18701 | RO 20-1724 | Ro-20-1724
TypeSmall organic molecule
Emp. Form.C15H22N2O3
Mol. Mass.278.3468
SMILESCCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Structure
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