| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor |
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| Ligand | BDBM50130293 |
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| Substrate/Competitor | n/a |
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| Ki | 74.3±n/a nM |
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| Comments | PDSP_3130 |
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| Citation |  Shapiro, DA; Renock, S; Arrington, E; Chiodo, LA; Liu, LX; Sibley, DR; Roth, BL; Mailman, R Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology28:1400-11 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Alpha-2A adrenergic receptor |
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| Name: | Alpha-2A adrenergic receptor |
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| Synonyms: | ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens] |
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| Type: | Enzyme |
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| Mol. Mass.: | 48979.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08913 |
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| Residue: | 465 |
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| Sequence: | MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS
FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR
RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP
AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR
TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50130293 |
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| n/a |
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| Name | BDBM50130293 |
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| Synonyms: | 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one | ARIPIPRAZOLE | CHEMBL1112 | US10174011, aripiprazole | US10752588, Compound Aripiprazole | US11498896, Compound Aripiprazole | US9018213, aripprazole | US9156822, Aripiprazole |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27Cl2N3O2 |
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| Mol. Mass. | 448.385 |
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| SMILES | Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl |
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| Structure | 
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