| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
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| Ligand | BDBM277404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical JAK Assay |
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| pH | 7.5±n/a |
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| Ki | <0.1±n/a nM |
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| Comments | extracted |
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| Citation |  Huang, X; Thalladi, VR Crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile US Patent US10072026 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 |
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| Name: | Tyrosine-protein kinase JAK2 |
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| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
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| Type: | Protein |
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| Mol. Mass.: | 130684.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674 |
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| Residue: | 1132 |
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| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM277404 |
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| n/a |
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| Name | BDBM277404 |
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| Synonyms: | N7-(5-methyl-1H-pyrazol-3-yl)-2-(morpholinomethyl)-N5-((1R,3s,5S)-8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octan-3-yl)-1,6-naphthyridine-5,7-diamine | US10072026, Example 15 | US10947254, Example 15 | US11780852, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33F3N8O |
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| Mol. Mass. | 530.5884 |
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| SMILES | Cc1cc(Nc2cc3nc(CN4CCOCC4)ccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CC(F)(F)F)n2)n[nH]1 |r,TLB:30:29:26.25:22.28.23| |
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| Structure | 
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