| Reaction Details |
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 | Report a problem with these data |
| Target | Protein disulfide-isomerase |
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| Ligand | BDBM86371 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Reductase Activity Assay |
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| pH | 7±0 |
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| IC50 | >1.0e+4±n/a nM |
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| Citation |  Khan, MM; Simizu, S; Lai, NS; Kawatani, M; Shimizu, T; Osada, H Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120. ACS Chem Biol6:245-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein disulfide-isomerase |
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| Name: | Protein disulfide-isomerase |
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| Synonyms: | Cellular thyroid hormone-binding protein | ERBA2L | P4HB | PDI | PDIA1 | PDIA1_HUMAN | PO4DB | Protein Disulfide-Isomerase (PDI) |
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| Type: | Protein |
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| Mol. Mass.: | 57084.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07237 |
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| Residue: | 508 |
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| Sequence: | MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALA
PEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGR
EADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAID
DIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEF
TEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQR
ILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQEL
PEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENI
VIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGD
DDDLEDLEEAEEPDMEEDDDQKAVKDEL
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| BDBM86371 |
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| n/a |
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| Name | BDBM86371 |
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| Synonyms: | Juniferdin derivative, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32O4 |
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| Mol. Mass. | 372.4978 |
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| SMILES | COc1ccc(cc1)C(=O)OC1C\C=C(C)\CCCC(C)(C)[C@H](O)\C=C1/C |r,c:14,t:25| |
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| Structure | 
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