| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-8 |
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| Ligand | BDBM277696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PBMC Cell Assay |
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| IC50 | 14.4±n/a nM |
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| Citation |  Fyfe, MC; Thom, SM Kinase inhibitors US Patent US10072034 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Interleukin-8 |
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| Name: | Interleukin-8 |
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| Synonyms: | CXCL8 | IL8 | IL8_HUMAN | MDNCF-a | interleukin 8 precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 11104.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_577736 |
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| Residue: | 99 |
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| Sequence: | MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
|
|
|
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| BDBM277696 |
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| n/a |
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| Name | BDBM277696 |
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| Synonyms: | 2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl) ureido)-naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxyphenoxy)ethoxyethoxy)-2-methylpropanoic acid | US10072034, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H51N5O11S |
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| Mol. Mass. | 845.957 |
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| SMILES | COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)(C)C(O)=O)c1 |
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| Structure | 
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