| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM28583 |
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| Substrate/Competitor | n/a |
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| Ki | 1.23±n/a nM |
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| Comments | PDSP_3217 |
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| Citation |  Hirst, WD; Abrahamsen, B; Blaney, FE; Calver, AR; Aloj, L; Price, GW; Medhurst, AD Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol64:1295-308 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47012.98 |
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| Organism: | MOUSE |
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| Description: | 5-HT6 HTR6 MOUSE::Q9R1C8 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQC
RLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQ
VPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCIS
PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHS
GARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNF
FVTDSVEPEIRQHPLGSPMN
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| BDBM28583 |
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| n/a |
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| Name | BDBM28583 |
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| Synonyms: | 5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride | CHEMBL431298 | SB 271046 | SB-271046 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22ClN3O3S2 |
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| Mol. Mass. | 451.99 |
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| SMILES | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1 |
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| Structure | 
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