| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50062912 |
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| Substrate/Competitor | n/a |
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| Ki | 152±n/a nM |
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| Comments | PDSP_1229 |
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| Citation |  Ukairo, OT; Bondi, CD; Newman, AH; Kulkarni, SS; Kozikowski, AP; Pan, S; Surratt, CK Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther314:575-83 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68749.45 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P23977 |
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| Residue: | 619 |
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| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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| BDBM50062912 |
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| n/a |
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| Name | BDBM50062912 |
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| Synonyms: | CHEMBL796 | Methylphenidate | alpha-phenyl-2-piperidineacetic acid methyl ester | methyl alpha-phenyl-alpha-(2-piperidyl)acetate | methyl alpha-phenyl-alpha-2-piperidinylacetate | methyl phenidylacetate | methyl phenyl(piperidin-2-yl)acetate | methylphenidan |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19NO2 |
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| Mol. Mass. | 233.3062 |
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| SMILES | COC(=O)C(C1CCCCN1)c1ccccc1 |
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| Structure | 
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