| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM86828 |
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| Substrate/Competitor | n/a |
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| Ki | 316±n/a nM |
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| Comments | PDSP_8347 |
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| Citation |  Stoit, AR; den Hartog, AP; Mons, H; van Schaik, S; Barkhuijsen, N; Stroomer, C; Coolen, HK; Reinders, JH; Adolfs, TJ; van der Neut, M; Keizer, H; Kruse, CG 7-Azaindole derivatives as potential partial nicotinic agonists. Bioorg Med Chem Lett18:188-93 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 70196.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P09483 |
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| Residue: | 630 |
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| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
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| BDBM86828 |
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| n/a |
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| Name | BDBM86828 |
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| Synonyms: | (R)-6-fluoro-2-(pyrrolidin-2-ylmethyl)-1H-pyrrolo[2,3-b]pyridine | (S)-6-fluoro-2-(pyrrolidin-2-ylmethyl)-1H-pyrrolo[2,3-b]pyridine | CAS_24758165 | CAS_24758289 | NSC_24758165 | NSC_24758289 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14FN3 |
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| Mol. Mass. | 219.2581 |
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| SMILES | Fc1ccc2cc(CC3CCCN3)[nH]c2n1 |
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| Structure | 
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