Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM86950 |
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Substrate/Competitor | n/a |
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Ki | 1.1±n/a nM |
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Comments | PDSP_8638 |
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Citation | Cunningham, CW; Mercer, SL; Hassan, HE; Traynor, JR; Eddington, ND; Coop, A Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. J Med Chem51:2316-20 (2008) [PubMed] Article |
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More Info.: | Get all data from this article |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM86950 |
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n/a |
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Name | BDBM86950 |
Synonyms: | CAS_5462505 | NSC_5462505 | heterocodeine |
Type | Small organic molecule |
Emp. Form. | C18H21NO3 |
Mol. Mass. | 299.3642 |
SMILES | COC1C=CC2C3Cc4ccc(O)c5OC1C2(CCN3C)c45 |c:3,TLB:4:5:19.18.17:7.8.21| |
Structure |
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