Reaction Details | |||
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Target | Tegument protein VP16 | ||
Ligand | BDBM50127140 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) | ||
IC50 | >35872±n/a nM | ||
Citation | PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay(2012)[AID] | ||
More Info.: | Get all data from this article, Assay Method | ||
Tegument protein VP16 | |||
Name: | Tegument protein VP16 | ||
Synonyms: | Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 54325.13 | ||
Organism: | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1) | ||
Description: | EBI_100271 | ||
Residue: | 490 | ||
Sequence: |
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BDBM50127140 | |||
n/a | |||
Name | BDBM50127140 | ||
Synonyms: | (-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside) | 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside | 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one | CHEMBL44657 | Etoposide (ET) | TRANS-ETOPOSIDE | VP-16 | etoposide | ||
Type | Small organic molecule | ||
Emp. Form. | C29H32O13 | ||
Mol. Mass. | 588.5566 | ||
SMILES | COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12 |r| | ||
Structure |