new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNuclear receptor coactivator 1
LigandBDBM87279
Substrate/Competitorn/a
Meas. Tech.Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1)
IC50 2843±n/a nM
Citation PubChem PC Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) PubChem Bioassay (2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor coactivator 1
Name:Nuclear receptor coactivator 1
Synonyms:Class E basic helix-loop-helix protein 74 | NCoA-1 | Protein Hin-2 | RIP160 | Renal carcinoma antigen NY-REN-52 | SRC-1 | Steroid receptor coactivator 1 | bHLHe74 | nuclear receptor coactivator 1 isoform 1
Type:PROTEIN
Mol. Mass.:156749.34
Organism:Homo sapiens (Human)
Description:ChEMBL_759690
Residue:1441
Sequence:
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
ADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT
E
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM87279
n/a
NameBDBM87279
Synonyms:2-Chloro-N-(1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-N-phenyl-acetamide | 2-chloro-N-(1,1-diketothiolan-3-yl)-N-phenyl-acetamide | 2-chloro-N-(1,1-dioxo-3-thiolanyl)-N-phenylacetamide | 2-chloro-N-(1,1-dioxothiolan-3-yl)-N-phenylacetamide | MLS000330976 | N-[1,1-bis(oxidanylidene)thiolan-3-yl]-2-chloranyl-N-phenyl-ethanamide | SMR000221075 | cid_2772172
TypeSmall organic molecule
Emp. Form.C12H14ClNO3S
Mol. Mass.287.762
SMILESClCC(=O)N(C1CCS(=O)(=O)C1)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: