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TargetPolyadenylate-binding protein 1
LigandBDBM32076
Substrate/Competitorn/a
Meas. Tech.Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50 36670±n/a nM
Citation PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
Polyadenylate-binding protein 1
Name:Polyadenylate-binding protein 1
Synonyms:PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:Enzyme Catalytic Domain
Mol. Mass.:70694.26
Organism:Homo sapiens (Human)
Description:gi_46367787
Residue:636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQ
QPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFS
AFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKERE
AELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKN
LDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
KPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRA
AYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQ
RVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQ
GQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESP
ESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
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  Blast E-value cutoff:
BDBM32076
n/a
NameBDBM32076
Synonyms:1-ethyl-2-[(1-methylimidazol-2-yl)sulfanylmethyl]benzimidazole-5-carboxylic acid | 1-ethyl-2-[[(1-methyl-2-imidazolyl)thio]methyl]-5-benzimidazolecarboxylic acid | 1-ethyl-2-[[(1-methylimidazol-2-yl)thio]methyl]benzimidazole-5-carboxylic acid | MLS000058666 | SMR000066468 | cid_2999671
TypeSmall organic molecule
Emp. Form.C15H16N4O2S
Mol. Mass.316.378
SMILESCCn1c(CSc2nccn2C)nc2cc(ccc12)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: