| Reaction Details |
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 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
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| Ligand | BDBM58947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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| IC50 | 20500±3170 nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| 26S proteasome non-ATPase regulatory subunit 14 |
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| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
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| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
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| Type: | Protein |
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| Mol. Mass.: | 34576.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00487 |
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| Residue: | 310 |
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| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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| BDBM58947 |
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| n/a |
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| Name | BDBM58947 |
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| Synonyms: | (2-Amino-5-methyl-thiophen-3-yl)-thiophen-2-yl-methanone | (2-amino-5-methyl-3-thienyl)-(2-thienyl)methanone | (2-amino-5-methyl-3-thiophenyl)-thiophen-2-ylmethanone | (2-amino-5-methylthiophen-3-yl)-thiophen-2-ylmethanone | (2-azanyl-5-methyl-thiophen-3-yl)-thiophen-2-yl-methanone | MLS000032456 | SMR000003162 | cid_644818 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9NOS2 |
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| Mol. Mass. | 223.315 |
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| SMILES | Cc1cc(C(=O)c2cccs2)c(N)s1 |
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| Structure | 
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