Ki Summary

Reaction Details

Report a problem with these data

Target

26S proteasome non-ATPase regulatory subunit 14

Ligand

BDBM41095

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay

IC50

4930±353 nM

Citation

PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]

More Info.:

Get all data from this article, Assay Method

26S proteasome non-ATPase regulatory subunit 14

Name:

26S proteasome non-ATPase regulatory subunit 14

Synonyms:

26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein

Type:

Protein

Mol. Mass.:

34576.68

Organism:

Homo sapiens (Human)

Description:

O00487

Residue:

310

Sequence:

MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK

BDBM41095

n/a

Name

BDBM41095

Synonyms:

5-[[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyano-vinyl]-2-methoxy-phenoxy]methyl]furan-2-carboxylic acid methyl ester | 5-[[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]methyl]-2-furancarboxylic acid methyl ester | MLS000581749 | SMR000200681 | cid_5740525 | methyl 5-({4-[2-(1H-benzimidazol-2-yl)-2-cyanovinyl]-2-methoxyphenoxy}methyl)-2-furoate | methyl 5-[[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyano-ethenyl]-2-methoxy-phenoxy]methyl]furan-2-carboxylate | methyl 5-[[4-[(E)-2-(1H-benzimidazol-2-yl)-2-cyanoethenyl]-2-methoxyphenoxy]methyl]furan-2-carboxylate

Type

Small organic molecule

Emp. Form.

C24H19N3O5

Mol. Mass.

429.4248

SMILES

COC(=O)c1ccc(COc2ccc(\C=C(/C#N)c3nc4ccccc4[nH]3)cc2OC)o1

Structure