| Reaction Details |
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 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
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| Ligand | BDBM45037 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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| IC50 | 3280±266 nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| 26S proteasome non-ATPase regulatory subunit 14 |
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| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
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| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
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| Type: | Protein |
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| Mol. Mass.: | 34576.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00487 |
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| Residue: | 310 |
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| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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| BDBM45037 |
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| n/a |
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| Name | BDBM45037 |
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| Synonyms: | (2Z)-2-[(2-hydroxy-5-nitro-anilino)methylene]benzothiophen-3-one | (2Z)-2-[(2-hydroxy-5-nitroanilino)methylidene]-1-benzothiophen-3-one | (2Z)-2-[[(5-nitro-2-oxidanyl-phenyl)amino]methylidene]-1-benzothiophen-3-one | 2-{[(2-hydroxy-5-nitrophenyl)amino]methylene}-1-benzothiophen-3(2H)-one | MLS000579149 | SMR000186737 | cid_5399788 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10N2O4S |
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| Mol. Mass. | 314.316 |
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| SMILES | Oc1ccc(cc1\[NH+]=C\[c-]1sc2ccccc2c1=O)[N+]([O-])=O |
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| Structure | 
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