Reaction Details | |||
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Target | 26S proteasome non-ATPase regulatory subunit 14 | ||
Ligand | BDBM48851 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay | ||
IC50 | 19500±1150 nM | ||
Citation | PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] | ||
More Info.: | Get all data from this article, Assay Method | ||
26S proteasome non-ATPase regulatory subunit 14 | |||
Name: | 26S proteasome non-ATPase regulatory subunit 14 | ||
Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein | ||
Type: | Protein | ||
Mol. Mass.: | 34576.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00487 | ||
Residue: | 310 | ||
Sequence: |
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BDBM48851 | |||
n/a | |||
Name | BDBM48851 | ||
Synonyms: | 2-[6-(2-fluorobenzyl)-4-keto-5,7-dimethyl-pyrrolo[3,4-d]pyridazin-3-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-(2-fluorobenzyl)-5,7-dimethyl-1-oxo-1,6-dihydro-2H-pyrrolo[3,4-d]pyridazin-2-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxidanylidene-pyrrolo[3,4-d]pyridazin-3-yl]-N-[2,3,5,6-tetrakis(fluoranyl)phenyl]ethanamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxo-3-pyrrolo[3,4-d]pyridazinyl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | 2-[6-[(2-fluorophenyl)methyl]-5,7-dimethyl-4-oxopyrrolo[3,4-d]pyridazin-3-yl]-N-(2,3,5,6-tetrafluorophenyl)acetamide | MLS000660595 | SMR000310114 | cid_16194171 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H17F5N4O2 | ||
Mol. Mass. | 476.3987 | ||
SMILES | Cc1n(Cc2ccccc2F)c(C)c2c1cnn(CC(=O)Nc1c(F)c(F)cc(F)c1F)c2=O | ||
Structure |