| Reaction Details |
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 | Report a problem with these data |
| Target | 26S proteasome non-ATPase regulatory subunit 14 |
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| Ligand | BDBM50731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay |
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| IC50 | 6760±339 nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| 26S proteasome non-ATPase regulatory subunit 14 |
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| Name: | 26S proteasome non-ATPase regulatory subunit 14 |
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| Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
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| Type: | Protein |
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| Mol. Mass.: | 34576.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00487 |
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| Residue: | 310 |
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| Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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| BDBM50731 |
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| n/a |
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| Name | BDBM50731 |
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| Synonyms: | (5E)-5-(3-furfurylidene)-1-(p-tolyl)barbituric acid | (5Z)-5-(3-furanylmethylidene)-1-(4-methylphenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-(3-furfurylidene)-1-(p-tolyl)barbituric acid | (5Z)-5-(furan-3-ylmethylidene)-1-(4-methylphenyl)-1,3-diazinane-2,4,6-trione | 5-[1-Furan-3-yl-meth-(Z)-ylidene]-1-p-tolyl-pyrimidine-2,4,6-trione | MLS000768294 | SMR000431615 | cid_1909760 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N2O4 |
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| Mol. Mass. | 296.2775 |
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| SMILES | Cc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2ccoc2)C1=O |w:14.15| |
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| Structure | 
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